Osteoprotegerin Gene as a Biomarker in the Development of Osteoporosis in Postmenopausal Women.

ABSTRACT: Osteoporosis is a multifactorial and polygenic disease caused by an imbalance between osteoclastogenesis and osteoblastogenesis, leading to a decrease in bone mineral density and the occurrence of disorders in the microarchitecture and metabolism of bone tissue. In postmenopausal women, there is a significant decrease in the production of estrogens, which play a key role in maintaining proper bone mineral density. Estrogens have an inhibitory effect on the development and activity of osteoclasts by reducing the synthesis of pro-resorption cytokines and stimulating the expression of osteoprotegerin (OPG). Osteoprotegerin is a cytokine that prevents bone loss by inhibiting the process of osteoclastogenesis, reducing bone resorption. The aim of our study was to determine the influence of the

SUBMITTER: Przerwa F 

PROVIDER: S-EPMC10740651 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature