Prediction of Antibody Viscosity from Dilute Solution Measurements.

ABSTRACT: The high antibody doses required to achieve a therapeutic effect often necessitate high-concentration products that can lead to challenging viscosity issues in production and delivery. Predicting antibody viscosity in early development can play a pivotal role in reducing late-stage development costs. In recent years, numerous efforts have been made to predict antibody viscosity through dilute solution measurements. A key finding is that the entanglement of long, flexible complexes contributes to the sharp rise in antibody viscosity at the required dosing. This entanglement model establishes a connection between the two-body binding affinity and the many-body viscosity. Exploiting this insight, this study connects dilute solution measurements of self-association to high-concentration viscos

SUBMITTER: Bhandari K 

PROVIDER: S-EPMC10740665 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature