Role of Fish Oil in Preventing Paternal Obesity and Improving Offspring Skeletal Muscle Health.

ABSTRACT: This study investigates the effects of fish oil supplementation during the periconceptional period in male mice. Specifically, it examines the impact of fish oil on intergenerational health, as determined by skeletal muscle markers. To mimic paternal obesity, thirty mice were separated into three groups with distinct dietary regimes for 10 weeks: a high-fat diet (HF), a high-fat diet supplemented with fish oil (FO), and a low-fat diet (LF). Then, these mice mated with control female mice. Dams and offspring consumed a chow diet during gestation and lactation, and the offspring continued on a chow diet. To study short-term (8 weeks) and long-term (16 weeks) effects of FO, skeletal muscle was isolated at the time of sacrifice, and gene analyses were performed. Results suggest that offspring

SUBMITTER: Xiong L 

PROVIDER: S-EPMC10740802 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature