Synthesis, Hydrolytic Stability and In Vivo Biological Study of Bioconjugates of the Tetrapeptides FELL Containing Pyrrole Moiety.

ABSTRACT:

Background

Bioconjugates are promising alternatives for the multiple targeting of any disease. Pyrrole heterocycle is well known with many activities and is a building block of a lot of medical drugs. On the other hand, peptides are short molecules with many advantages such as small size, ability to penetrate the cell membrane and bond-specific receptors, vectorizing potential, etc. Thus, hybrid molecules between peptide and pyrrole moiety could be a promising alternative as an anti-pain tool.

Methods

New bioconjugates with a general formula Pyrrole (α-/β-acid)-FELL-OH (NH₂) were synthesized using Fmoc/OtBu peptide synthesis on solid support. HPLC was used to monitor the purity of newly synthesized bioconjugates. Their structures were proven by electrospray ioniza

SUBMITTER: Borisova B 

PROVIDER: S-EPMC10740831 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature