Neuroprotective Action of Humanin and Humanin Analogues: Research Findings and Perspectives.

ABSTRACT: Humanin is a 24-mer peptide first reported in the early 2000s as a new neuroprotective/cytoprotective factor rescuing neuronal cells from death induced by various Alzheimer's disease-associated insults. Nowadays it is known that humanin belongs to the novel class of the so-called mitochondrial-derived peptides (which are encoded by mitochondrial DNA) and has been shown to exert beneficial cytoprotective effects in a series of in vitro and/or in vivo experimental models of human diseases, including not only neurodegenerative disorders but other human diseases as well (e.g., age-related macular degeneration, cardiovascular diseases, or diabetes mellitus). This review article is focused on the presentation of recent in vitro and in vivo research results associated with the neuroprotective act

SUBMITTER: Karachaliou CE 

PROVIDER: S-EPMC10740898 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature