Recent Developments in Gene Therapy for Neovascular Age-Related Macular Degeneration: A Review.

ABSTRACT: Age-related macular degeneration (AMD) is a complex and multifactorial disease and a leading cause of irreversible blindness in the elderly population. The anti-vascular endothelial growth factor (anti-VEGF) therapy has revolutionized the management and prognosis of neovascular AMD (nAMD) and is currently the standard of care for this disease. However, patients are required to receive repeated injections, imposing substantial social and economic burdens. The implementation of gene therapy methods to achieve sustained delivery of various therapeutic proteins holds the promise of a single treatment that could ameliorate the treatment challenges associated with chronic intravitreal therapy, and potentially improve visual outcomes. Several early-phase trials are currently underway, evaluating

SUBMITTER: Finocchio L 

PROVIDER: S-EPMC10740940 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature