Strategies to Name Metallo-β-Lactamases and Number Their Amino Acid Residues.

ABSTRACT: Metallo-β-lactamases (MBLs), also known as class B β-lactamases (BBLs), are Zn(II)-containing enzymes able to inactivate a broad range of β-lactams, the most commonly used antibiotics, including life-saving carbapenems. They have been known for about six decades, yet they have only gained much attention as a clinical problem for about three decades. The naming conventions of these enzymes have changed over time and followed various strategies, sometimes leading to confusion. We are summarizing the naming strategies of the currently known MBLs. These enzymes are quite diverse on the amino acid sequence level but structurally similar. Problems trying to describe conserved residues, such as Zn(II) ligands and other catalytically important residues, which have different numbers in different se

SUBMITTER: Oelschlaeger P 

PROVIDER: S-EPMC10740994 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature