Metabolomics, Lipidomics, and Antipsychotics: A Systematic Review.

ABSTRACT: Antipsychotics are an important pharmacotherapy option for the treatment of many mental illnesses. Unfortunately, selecting antipsychotics is often a trial-and-error process due to a lack of understanding as to which medications an individual patient will find most effective and best tolerated. Metabolomics, or the study of small molecules in a biosample, is an increasingly used omics platform that has the potential to identify biomarkers for medication efficacy and toxicity. This systematic review was conducted to identify metabolites and metabolomic pathways associated with antipsychotic use in humans. Ultimately, 42 studies were identified for inclusion in this review, with all but three studies being performed in blood sources such as plasma or serum. A total of 14 metabolite classes a

SUBMITTER: Burghardt KJ 

PROVIDER: S-EPMC10741000 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature