A Peptoid-Chelator Selective to Cu²⁺ That Can Extract Copper from Metallothionein-2 and Lead to the Production of ROS.

ABSTRACT: Copper is an essential metal ion that is involved in critical cellular processes, but which can also exhibit toxic effects through its ability to catalyze reactive oxygen species (ROS) formation. Dysregulation of copper homeostasis has been implicated in the progression of several diseases, including cancer. A novel therapeutic approach, extensively studied in recent years, is to capitalize on the increased copper uptake and dependency exhibited by cancer cells and to promote copper-associated ROS production within the tumor microenvironment, leading to the apoptosis of cancer cells. Such an effect can be achieved by selectively chelating copper from copper-bearing metalloproteins in cancer cells, thereby forming a copper-chelator complex that produces ROS and, through this, induces oxidat

SUBMITTER: Behar AE 

PROVIDER: S-EPMC10741037 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature