AST-001 Improves Social Deficits and Restores Dopamine Neuron Activity in a Mouse Model of Autism.

ABSTRACT: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impaired social communication and social interaction, restricted and repetitive behavior, and interests. The core symptoms of ASD are associated with deficits in mesocorticolimbic dopamine pathways that project from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC). AST-001 is an investigational product currently in a phase 3 clinical trial for treating the core symptoms of ASD, with L-serine as the API (active pharmaceutical ingredient). Because the causes of ASD are extremely heterogeneous, a single genetic ASD model cannot represent all autism models. In this paper, we used the VPA-exposed model, which is more general and widely used than a single ge

SUBMITTER: Um KB 

PROVIDER: S-EPMC10741043 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature