Targeting the Adipose Tissue-Liver-Gut Microbiota Crosstalk to Cure MASLD.

ABSTRACT: The gut microbiota is a complex system, playing a peculiar role in regulating innate and systemic immunity. Increasing evidence links dysfunctional gut microbiota to metabolic dysfunction-associated steatotic liver disease (MASLD) due to the activation of multiple pathways in the gut and in the liver, including those mediated by Toll-like receptors (TLRs), that sustain hepatic inflammation. Thus, many efforts have been made to unravel the role of microbiota-associated dysfunction in MASLD, with the final aim of finding novel strategies to improve liver steatosis and function. Moreover, recent evidence underlines the role of adipose tissue in sustaining hepatic inflammation during MASLD development. In this review, we focus on the recently discovered strategies proposed to improve the alter

SUBMITTER: Gabbia D 

PROVIDER: S-EPMC10741127 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature