3-Substituted Coumarins Inhibit NorA and MepA Efflux Pumps of Staphylococcus aureus.

ABSTRACT: Coumarins are compounds with scientifically proven antibacterial properties, and modifications to the chemical structure are known to improve their effects. This information is even more relevant with the unbridled advances of antibiotic resistance, where Staphylococcus aureus and its efflux pumps play a prominent role. The study's objective was to evaluate the potential of synthetic coumarins with different substitutions in the C-3 position as possible inhibitors of the NorA and MepA efflux pumps of S. aureus. For this evaluation, the following steps took place: (i) the determination of the minimum inhibitory concentration (MIC); (ii) the association of coumarins with fluoroquinolones and ethidium bromide (EtBr); (iii) the assessment of the effect on EtBr fluorescence emissi

SUBMITTER: Araujo-Neto JB 

PROVIDER: S-EPMC10741188 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature