Risk for Seasonal Affective Disorder (SAD) Linked to Circadian Clock Gene Variants.

ABSTRACT: Molecular pathways affecting mood are associated with circadian clock gene variants and are influenced, in part, by the circadian clock, but the molecular mechanisms underlying this link are poorly understood. We use machine learning and statistical analyses to determine the circadian gene variants and clinical features most highly associated with symptoms of seasonality and seasonal affective disorder (SAD) in a deeply phenotyped population sample. We report sex-specific clock gene effects on seasonality and SAD symptoms; genotypic combinations of CLOCK3111/ZBTB20 and PER2/PER3B were significant genetic risk factors for males, and CRY2/PER3C and CRY2/PER3-VNTR were significant risk factors for females. Anxiety, eveningness, and increasing age were significant clinical risk factors for sea

SUBMITTER: Dang T 

PROVIDER: S-EPMC10741218 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature