Exogenous Oxytocin Administration Restores Memory in Female APP/PS1 Mice.

ABSTRACT:

Background

Current treatment options for Alzheimer's disease (AD) are limited, inefficient, and often have serious side effects. Oxytocin is a neuropeptide implicated in a variety of central processes, such as social and reproductive behaviors. Among others, it has garnered attention in various domains of psychiatric research, while its role in the development and course of neurodegenerative disorders like AD is rather unknown.

Objective

This study aimed to investigate the role of exogenous oxytocin administration on memory, specifically in view of AD, as a potential novel treatment option.

Methods

We describe a novel treatment approach by using a relatively low dose of long-term intranasal oxytocin treatment, to restore memory deficits in female APPswePS1dE9 mice.

SUBMITTER: Koulousakis P 

PROVIDER: S-EPMC10741313 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature