Association of Tooth Loss with Alzheimer's Disease Tau Pathologies Assessed by Positron Emission Tomography.

ABSTRACT:

Background

Deterioration of the oral environment is one of the risk factors for dementia. A previous study of an Alzheimer's disease (AD) model mouse suggests that tooth loss induces denervation of the mesencephalic trigeminal nucleus and neuroinflammation, possibly leading to accelerated tau dissemination from the nearby locus coeruleus (LC).

Objective

To elucidate the relevance of oral conditions and amyloid-β (Aβ) and tau pathologies in human participants.

Methods

We examined the number of remaining teeth and the biofilm-gingival interface index in 24 AD-spectrum patients and 19 age-matched healthy controls (HCs). They also underwent positron emission tomography (PET) imaging of Aβ and tau with specific radiotracers, 11C-PiB and 18F-PM-PBB3, respectively. All AD-sp

SUBMITTER: Matsumoto H 

PROVIDER: S-EPMC10741329 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature