Proteome Network Analysis Identifies Potential Biomarkers for Brain Aging.

ABSTRACT:

Background

Alzheimer's disease and related dementias (ADRD) involve biological processes that begin years to decades before onset of clinical symptoms. The plasma proteome can offer insight into brain aging and risk of incident dementia among cognitively healthy adults.

Objective

To identify biomarkers and biological pathways associated with neuroimaging measures and incident dementia in two large community-based cohorts by applying a correlation-based network analysis to the plasma proteome.

Methods

Weighted co-expression network analysis of 1,305 plasma proteins identified four modules of co-expressed proteins, which were related to MRI brain volumes and risk of incident dementia over a median 20-year follow-up in Framingham Heart Study (FHS) Offspring cohort partic

SUBMITTER: Short MI 

PROVIDER: S-EPMC10741337 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature