Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria.

ABSTRACT: Conjugative plasmids play a key role in the dissemination of antimicrobial resistance (AMR) genes across bacterial pathogens. AMR plasmids are widespread in clinical settings, but their distribution is not random, and certain associations between plasmids and bacterial clones are particularly successful. For example, the globally spread carbapenem resistance plasmid pOXA-48 can use a wide range of enterobacterial species as hosts, but it is usually associated with a small number of specific Klebsiella pneumoniae clones. These successful associations represent an important threat for hospitalized patients. However, knowledge remains limited about the factors determining AMR plasmid distribution in clinically relevant bacteria. Here, we combined in vitro and in vivo experimental appro

SUBMITTER: Alonso-Del Valle A 

PROVIDER: S-EPMC10741383 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature