Exploring the Safety of Pllans-II and Antitumoral Potential of Its Recombinant Isoform in Cervical Cancer Therapy.

ABSTRACT: The antitumor potential of proteins from snake venoms has been studied in recent decades, and evidence has emerged that phospholipases A₂ can selectively attack cells of various types of tumors. Previous results have shown that phospholipase A₂ "Pllans-II," isolated from Porthidium lansbergii lansbergii snake venom, displayed antitumoral activity on cervical cancer and did not alter the viability of non-tumorigenic cells. However, until now, there was no evidence of its safety at the local and systemic levels, nor had experiments been developed to demonstrate that its production using recombinant technology allows us to obtain a molecule with effects similar to those generated by native phospholipase. Thus, we evaluated the impact caused by Pll

SUBMITTER: Sevilla-Sanchez MJ 

PROVIDER: S-EPMC10741390 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature