Controlling the Nucleation and Growth of Salt from Bodily Fluid for Enhanced Biosensing Applications.

ABSTRACT: Surface-enhanced Raman spectroscopy (SERS) represents a transformative tool in medical diagnostics, particularly for the early detection of key biomarkers such as small extracellular vesicles (sEVs). Its unparalleled sensitivity and compatibility with intricate biological samples make it an ideal candidate for revolutionizing noninvasive diagnostic methods. However, a significant challenge that mars its efficacy is the throughput limitation, primarily anchored in the prerequisite of hotspot and sEV colocalization within a minuscule range. This paper delves deep into this issue, introducing a never-attempted-before approach which harnesses the principles of crystallization-nucleation and growth. By synergistically coupling lasers with plasmonic resonances, we navigate the challenges associa

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC10741434 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature