Functional and Molecular Heterogeneity in Glioma Stem Cells Derived from Multiregional Sampling.

ABSTRACT: Glioblastoma (GBM) is an aggressive and highly heterogeneous primary brain tumor. Glioma stem cells represent a subpopulation of tumor cells with stem cell traits that are presumed to be the cause of tumor relapse. There exists complex tumor heterogeneity in drug sensitivity patterns between glioma stem cell (GSC) cultures derived from different patients. Here, we describe that heterogeneity also exists between GSC cultures derived from multiple biopsies within a single tumor. From biopsies harvested within spatially distinct regions representing the entire tumor mass, we established seven GSC cultures and compared their stem cell properties, mutations, gene expression profiles, and drug sensitivity patterns against 115 different anticancer drugs. The results were compared to 14 GSC cultur

SUBMITTER: Brynjulvsen M 

PROVIDER: S-EPMC10741477 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature