The impact of platelet indices on ischemic stroke: a Mendelian randomization study and mediation analysis.

ABSTRACT:

Introduction

Platelet indices (PIs) are hematological parameters that indicate the number, morphology, and activation of platelets. Although some clinical trials suggest an association between PIs and the risk of stroke, the lack of robust evidence is attributed to confounding effects and reverse causation.

Objective

This study aimed to evaluate the association between PIs and stroke risk through Mendelian randomization (MR) while exploring the mediating effect of blood pressure in this association.

Methods

We identified genetic variants associated with PIs, including platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and platelet crit (PCT), in the UK Biobank (n = 350,474). Relevant genome-wide association studies were utilize

SUBMITTER: Li Y 

PROVIDER: S-EPMC10741650 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature