Alpha 2-Macroglobulin Polymorphisms and Susceptibility to Alzheimer's Disease: A Comprehensive Meta-Analysis Based on 62 Studies.

ABSTRACT:

Background

The relationship between alpha 2-macroglobulin (A2M) gene and Alzheimer's disease (AD) has been widely studied across populations; however, the results are inconsistent.

Objective

This study aimed to evaluate the association of A2M gene with AD by the application of meta-analysis.

Methods

Relevant studies were identified by comprehensive searches. The quality of each study was assessed using the Newcastle-Ottawa Scale. Allele and genotype frequencies were extracted from each of the included studies. Odds ratio (OR) with corresponding 95% confidence intervals (CI) was calculated using a random-effects or fixed-effects model. The Cochran Q statistic and I² metric was used to evaluate heterogeneity, and Egger's test and Funnel plot were used to asse

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10741958 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature