Proton Reirradiation for High-Risk Recurrent or New Primary Breast Cancer.

ABSTRACT: Radiotherapy is an integral component of multidisciplinary breast cancer care. Given how commonly radiotherapy is used in the treatment of breast cancer, many patients with recurrences have received previous radiotherapy. Patients with new primary breast cancer may also have received previous radiotherapy to the thoracic region. Curative doses and comprehensive field photon reirradiation (reRT) have often been avoided in these patients due to concerns for severe toxicities to organs-at-risk (OARs), such as the heart, lungs, brachial plexus, and soft tissue. However, many patients may benefit from definitive-intent reRT, such as patients with high-risk disease features such as lymph node involvement and dermal/epidermal invasion. Proton therapy is a potentially advantageous treatment option

SUBMITTER: Chakraborty MA 

PROVIDER: S-EPMC10742022 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature