Contributions of Vascular Burden and Amyloid Abnormality to Cognitive Decline in Memory Clinic Patients.

ABSTRACT:

Background

Alzheimer's disease pathology and vascular burden are highly prevalent and often co-occur in elderly. It remains unclear how both relate to cognitive decline.

Objective

To investigate whether amyloid abnormality and vascular burden synergistically contribute to cognitive decline in a memory clinic population.

Methods

We included 227 patients from Maastricht and Aachen memory clinics. Amyloid abnormality (A+) was defined by CSF Aβ₄₂ using data-driven cut-offs. Vascular burden (V+) was defined as having moderate to severe white matter hyperintensities, or any microbleeds, macrohemorrhage or infarcts on MRI. Longitudinal change in global cognition, memory, processing speed, executive functioning, and verbal fluency was analysed across the A-V-, A-V+

SUBMITTER: van Gils V 

PROVIDER: S-EPMC10742024 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature