Magnetic Resonance Imaging of Macrophage Response to Radiation Therapy.

ABSTRACT:

Background

Magnetic resonance imaging (MRI) is a non-invasive imaging modality which, in conjunction with biopsies, provide a qualitative assessment of tumor response to treatment. Intravenous injection of contrast agents such as fluorine (¹⁹F) nanoemulsions labels systemic macrophages, which can, then, be tracked in real time with MRI. This method can provide quantifiable insights into the behavior of tumor-associated macrophages (TAMs) in the tumor microenvironment and macrophage recruitment during therapy.

Methods

Female mice received mammary fat pad injections of murine breast or colon cancer cell lines. The mice then received an intravenous ¹⁹F nanoemulsion injection, followed by a baseline ¹⁹F MRI. For each cancer model, half of the mic

SUBMITTER: Yang H 

PROVIDER: S-EPMC10742077 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature