Exploring the Potential Mechanism of Action of Piperine against Candida albicans and Targeting Its Virulence Factors.

ABSTRACT: Plant-derived compounds have proven to be a source of inspiration for new drugs. In this study, piperine isolated from the fruits of Piper nigrum showed anti-Candida activity. Furthermore, the mechanisms of action of piperine and its impact on virulence factors in Candida albicans, which have not been comprehensively understood, were also assessed. Initially, piperine suppressed the hyphal transition in both liquid and solid media, hindered biofilm formation, and resulted in observable cell distortions in scanning electron microscope (SEM) samples, for both fluconazole-sensitive and fluconazole-resistant C. albicans strains. Additionally, the morphogenetic switches triggered by piperine were found to rely on the activity of mutant C. albicans strains. Sec

SUBMITTER: Bravo-Chaucanes CP 

PROVIDER: S-EPMC10742119 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature