Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations.

ABSTRACT:

Background

Proteins targeted by the ubiquitin proteasome system (UPS) are identified for degradation by the proteasome, which has been implicated in the development of neurodegenerative diseases. Major histocompatibility complex (MHC) molecules present peptides broken down by the proteasome and are involved in neuronal plasticity, regulating the synapse number and axon regeneration in the central or peripheral nervous system during development and in brain diseases. The mechanisms governing these effects are mostly unknown, but evidence from different compartments of the cerebral cortex indicates the presence of immune-like MHC receptors in the central nervous system.

Methods

We used human induced pluripotent stem cells (iPSCs) differentiated into neural stem cells and then

SUBMITTER: Alvarez I 

PROVIDER: S-EPMC10742145 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature