A Comparative Kidney Transcriptome Analysis of Bicarbonate-Loaded insrr-Null Mice.

ABSTRACT: The maintenance of plasma pH is critical for life in all organisms. The kidney plays a critical role in acid-base regulation in vertebrates by controlling the plasma concentration of bicarbonate. The receptor tyrosine kinase IRR (insulin receptor-related receptor) is expressed in renal β-intercalated cells and is involved in alkali sensing due to its ability to autophosphorylate under alkalization of extracellular medium (pH > 7.9). In mice with a knockout of the insrr gene, which encodes for IRR, urinary bicarbonate secretion in response to alkali loading is impaired. The specific regulatory mechanisms in the kidney that are under the control of IRR remain unknown. To address this issue, we analyzed and compared the kidney transcriptomes of wild-type and insrr knockout mice

SUBMITTER: Gantsova EA 

PROVIDER: S-EPMC10742211 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature