Attenuation Correction of Long Axial Field-of-View Positron Emission Tomography Using Synthetic Computed Tomography Derived from the Emission Data: Application to Low-Count Studies and Multiple Tracers.

ABSTRACT: Recent advancements in PET/CT, including the emergence of long axial field-of-view (LAFOV) PET/CT scanners, have increased PET sensitivity substantially. Consequently, there has been a significant reduction in the required tracer activity, shifting the primary source of patient radiation dose exposure to the attenuation correction (AC) CT scan during PET imaging. This study proposes a parameter-transferred conditional generative adversarial network (PT-cGAN) architecture to generate synthetic CT (sCT) images from non-attenuation corrected (NAC) PET images, with separate networks for [¹⁸F]FDG and [¹⁵O]H₂O tracers. The study includes a total of 1018 subjects (n = 972 [¹⁸F]FDG, n = 46 [¹⁵O]H₂O). Testing was perfor

SUBMITTER: Montgomery ME 

PROVIDER: S-EPMC10742516 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature