Diagnostic Accuracy of PET with ¹⁸F-Fluciclovine ([¹⁸F]FACBC) in Detecting High-Grade Gliomas: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

¹⁸F-Fluciclovine ([¹⁸F]FACBC) has been recently proposed as a synthetic radiolabeled amino acid for positron emission tomography (PET) imaging in patients with brain neoplasms. Our aim is to evaluate the diagnostic performance of [¹⁸F]FACBC PET in high-grade glioma (HGG) patients, taking into account the literature data.

Methods

A comprehensive literature search was performed. We included original articles evaluating [¹⁸F]FACBC PET in the detection of HGG before therapy and for the suspicion of tumor recurrence. Pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR-), and diagnostic odds ratios (DOR), including 95% confidence intervals (95% CI), were measured. Statistical heterogeneity and

SUBMITTER: Castello A 

PROVIDER: S-EPMC10742552 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature