Dual Targeting of DNA Damage Response Proteins Implicated in Cancer Radioresistance.

ABSTRACT: Ionizing radiation can induce different types of DNA lesions, leading to genomic instability and ultimately cell death. Radiation therapy or radiotherapy, a major modality in cancer treatment, harnesses the genotoxic potential of radiation to target and destroy cancer cells. Nevertheless, cancer cells have the capacity to develop resistance to radiation treatment (radioresistance), which poses a major obstacle in the effective management of cancer. It has been shown that administration of platinum-based drugs to cancer patients can increase tumor radiosensitivity, but despite this, it is associated with severe adverse effects. Several lines of evidence support that activation of the DNA damage response and repair machinery in the irradiated cancer cells enhances radioresistance and cellula

SUBMITTER: Vasilopoulos SN 

PROVIDER: S-EPMC10742610 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature