Expression of Human L-Dopa Decarboxylase (DDC) under Conditions of Oxidative Stress.

ABSTRACT: Oxidative stress is known to influence mRNA levels, translation, and proteolysis. The importance of oxidative stress has been demonstrated in several human diseases, including neurodegenerative disorders. L-Dopa decarboxylase (DDC) is the enzyme that converts L-Dopa to dopamine (DA). In spite of a large number of studies, little is known about the biological significance of the enzyme under physiological and pathological conditions. Here, we investigated the relationship between DDC expression and oxidative stress in human neural and non-neural cells. Oxidative stress was induced by treatment with H₂O₂. Our data indicated that mRNA and protein expression of DDC was enhanced or remained stable under conditions of ROS induction, despite degradation of total RNA and incr

SUBMITTER: Lotsios NS 

PROVIDER: S-EPMC10742706 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature