Exploring the Role of the Gut and Intratumoral Microbiomes in Tumor Progression and Metastasis.

ABSTRACT: Cancer cell dissemination involves invasion, migration, resistance to stressors in the circulation, extravasation, colonization, and other functions responsible for macroscopic metastases. By enhancing invasiveness, motility, and intravasation, the epithelial-to-mesenchymal transition (EMT) process promotes the generation of circulating tumor cells and their collective migration. Preclinical and clinical studies have documented intensive crosstalk between the gut microbiome, host organism, and immune system. According to the findings, polymorphic microbes might play diverse roles in tumorigenesis, cancer progression, and therapy response. Microbial imbalances and changes in the levels of bacterial metabolites and toxins promote cancer progression via EMT and angiogenesis. In contrast, a fa

SUBMITTER: Sevcikova A 

PROVIDER: S-EPMC10742837 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature