Transcriptome Profiling after Early Spinal Cord Injury in the Axolotl and Its Comparison with Rodent Animal Models through RNA-Seq Data Analysis.

ABSTRACT:

Background

Traumatic spinal cord injury (SCI) is a disabling condition that affects millions of people around the world. Currently, no clinical treatment can restore spinal cord function. Comparison of molecular responses in regenerating to non-regenerating vertebrates can shed light on neural restoration. The axolotl (Ambystoma mexicanum) is an amphibian that regenerates regions of the brain or spinal cord after damage.

Methods

In this study, we compared the transcriptomes after SCI at acute (1-2 days after SCI) and sub-acute (6-7 days post-SCI) periods through the analysis of RNA-seq public datasets from axolotl and non-regenerating rodents.

Results

Genes related to wound healing and immune responses were upregulated in axolotls, rats, and mice after SCI; how

SUBMITTER: Gonzalez-Orozco JC 

PROVIDER: S-EPMC10742908 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature