Potential Causal Association between Depression and Oral Diseases: A Mendelian Randomization Study.

ABSTRACT:

Background

Globally, oral diseases are common, pose an economic burden, and significantly decline the quality of life of affected individuals. Recently, researchers have substantially highlighted the effect of depression on oral disease incidence and development. In this study, we elucidated the correlation between depression and oral diseases.

Methods

Using two-sample Mendelian randomization (MR), the association between depression and the risk of 17 oral diseases was evaluated. Three methods were used to perform MR analysis: the inverse variance-weighted, weighted median, and MR-Egger methods. Furthermore, Cochran's Q test, MR-Egger intercept test, MR Pleiotropy RESidual Sum and Outlier test, and leave-one-out analysis were performed to analyze sensitivity.

Results

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10742945 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature