A Critical Analysis of the Robustness of Radiomics to Variations in Segmentation Methods in ¹⁸F-PSMA-1007 PET Images of Patients Affected by Prostate Cancer.

ABSTRACT:

Background

Radiomics shows promising results in supporting the clinical decision process, and much effort has been put into its standardization, thus leading to the Imaging Biomarker Standardization Initiative (IBSI), that established how radiomics features should be computed. However, radiomics still lacks standardization and many factors, such as segmentation methods, limit study reproducibility and robustness.

Aim

We investigated the impact that three different segmentation methods (manual, thresholding and region growing) have on radiomics features extracted from ¹⁸F-PSMA-1007 Positron Emission Tomography (PET) images of 78 patients (43 Low Risk, 35 High Risk). Segmentation was repeated for each patient, thus leading to three datasets of segmentations. Then, f

SUBMITTER: Pasini G 

PROVIDER: S-EPMC10743045 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature