Unknown

Dataset Information

0

Evolution of Systemic Therapy in Medulloblastoma Including Irradiation-Sparing Approaches.


ABSTRACT: The management of medulloblastoma in children has dramatically changed over the past four decades, with the development of chemotherapy protocols aiming at improving survival and reducing long-term toxicities of high-dose craniospinal radiotherapy. While the staging and treatment of medulloblastoma were until recently based on the modified Chang's system, recent advances in the molecular biology of medulloblastoma have revolutionized approaches in the management of this increasingly complex disease. The evolution of systemic therapies is described in this review.

SUBMITTER: Mushtaq N 

PROVIDER: S-EPMC10743079 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Evolution of Systemic Therapy in Medulloblastoma Including Irradiation-Sparing Approaches.

Mushtaq Naureen N   Ul Ain Rahat R   Hamid Syed Ahmer SA   Bouffet Eric E  

Diagnostics (Basel, Switzerland) 20231216 24


The management of medulloblastoma in children has dramatically changed over the past four decades, with the development of chemotherapy protocols aiming at improving survival and reducing long-term toxicities of high-dose craniospinal radiotherapy. While the staging and treatment of medulloblastoma were until recently based on the modified Chang's system, recent advances in the molecular biology of medulloblastoma have revolutionized approaches in the management of this increasingly complex dise  ...[more]

Similar Datasets

| S-EPMC7543681 | biostudies-literature
| S-EPMC8019572 | biostudies-literature
| S-EPMC5514252 | biostudies-other
| S-EPMC5554005 | biostudies-literature
| S-EPMC6839384 | biostudies-literature
| S-EPMC10107770 | biostudies-literature
| S-EPMC10028073 | biostudies-literature
| S-EPMC4657242 | biostudies-other
| S-EPMC5466873 | biostudies-literature
| S-EPMC3956350 | biostudies-literature