Reprogramming in Candida albicans Gene Expression Network under Butanol Stress Abrogates Hyphal Development.

ABSTRACT: Candida albicans is the causative agent of invasive fungal infections. Its hyphae-forming ability is regarded as one of the important virulence factors. To unravel the impact of butanol on Candida albicans, it was placed in O^+ve complete human serum with butanol (1% v/v). The Candida transcriptome under butanol stress was then identified by mRNA sequencing. Studies including electron microscopy demonstrated the inhibition of hyphae formation in Candida under the influence of butanol, without any significant alteration in growth rate. The numbers of genes upregulated in the butanol in comparison to the serum alone were 1061 (20 min), 804 (45 min), and 537 (120 min). Candida cells exhibited the downregulation of six hypha-specific t

SUBMITTER: Anand R 

PROVIDER: S-EPMC10743114 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature