Mitochondrial p38 Mitogen-Activated Protein Kinase: Insights into Its Regulation of and Role in LONP1-Deficient Nematodes.

ABSTRACT: p38 Mitogen-Activated Protein Kinase (MAPK) cascades are central regulators of numerous physiological cellular processes, including stress response signaling. In C. elegans, mitochondrial dysfunction activates a PMK-3/p38 MAPK signaling pathway (MAPK^mt), but its functional role still remains elusive. Here, we demonstrate the induction of MAPK^mt in worms deficient in the lonp-1 gene, which encodes the worm ortholog of mammalian mitochondrial LonP1. This induction is subjected to negative regulation by the ATFS-1 transcription factor through the CREB-binding protein (CBP) ortholog CBP-3, indicating an interplay between both activated MAPK^mt and mitochondrial Unfolded Protein Response (UPR^mt) surveillance pathways. Our results also rev

SUBMITTER: Taouktsi E 

PROVIDER: S-EPMC10743222 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature