Ontology highlight
ABSTRACT:
SUBMITTER: Qi C
PROVIDER: S-EPMC10743375 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Qi Chao C Verheijen Bert M BM Kokubo Yasumasa Y Shi Yang Y Tetter Stephan S Murzin Alexey G AG Nakahara Asa A Morimoto Satoru S Vermulst Marc M Sasaki Ryogen R Aronica Eleonora E Hirokawa Yoshifumi Y Oyanagi Kiyomitsu K Kakita Akiyoshi A Ryskeldi-Falcon Benjamin B Yoshida Mari M Hasegawa Masato M Scheres Sjors H W SHW Goedert Michel M
Proceedings of the National Academy of Sciences of the United States of America 20231215 51
The amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of the island of Guam and the Kii peninsula of Japan is a fatal neurodegenerative disease of unknown cause that is characterized by the presence of abundant filamentous tau inclusions in brains and spinal cords. Here, we used electron cryo-microscopy to determine the structures of tau filaments from the cerebral cortex of three cases of ALS/PDC from Guam and eight cases from Kii, as well as from the spinal cord of two of t ...[more]