MiR-889-3p Facilitates the Browning Process of White Adipocyte Precursors by Targeting the SON Gene.

ABSTRACT: It is well-established that beige/brown adipose tissue can dissipate stored energy through thermogenesis; hence, the browning of white adipocytes (WAT) has garnered significant interest in contemporary research. Our preceding investigations have identified a marked downregulation of miR-889-3p concurrent with the natural maturation of brown adipose tissue. However, the specific role and underlying molecular mechanisms of miR-889-3p in the browning process of white adipose tissue warrant further elucidation. In this research, we initially delved into the potential role of miR-889-3p in preadipocyte growth via flow cytometry and CCK-8 assay, revealing that miR-889-3p can stimulate preadipocyte growth. To validate the potential contribution of miR-889-3p in the browning process of white adipo

SUBMITTER: Sun W 

PROVIDER: S-EPMC10743546 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature