The Dynamics of OXA-23 β-Lactamase from Acinetobacter baumannii.

ABSTRACT: Antibiotic resistance is a pressing topic, which also affects β-lactam antibiotic molecules. Until a few years ago, it was considered no more than an interesting species from an academic point of view, Acinetobacter baumanii is today one of the most serious threats to public health, so much so that it has been declared one of the species for which the search for new antibiotics, or new ways to avoid its resistance, is an absolute priority according to WHO. Although there are several molecular mechanisms that are responsible for the extreme resistance of A. baumanii to antibiotics, a class D β-lactamase is the main cause for the clinical concern of this bacterial species. In this work, we analyzed the A. baumanii OXA-23 protein via molecular dynamics. The results obtain

SUBMITTER: Arrigoni R 

PROVIDER: S-EPMC10743560 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature