Abnormal interhemispheric functional cooperation in schizophrenia follows the neurotransmitter profiles.

ABSTRACT:

Background

Interhemispheric cooperation is one of the most prominent functional architectures of the human brain. In patients with schizophrenia, interhemispheric cooperation deficits have been reported using increasingly powerful neurobehavioural and neuroimaging measures. However, these methods rely in part on the assumption of anatomic symmetry between hemispheres. In the present study, we explored interhemispheric cooperation deficits in schizophrenia using a newly developed index, connectivity between functionally homotopic voxels (CFH), which is unbiased by hemispheric asymmetry.

Methods

Patients with schizophrenia and age- and sexmatched healthy controls underwent multimodal MRI, and whole-brain CFH maps were constructed for comparison between groups. We examined the

SUBMITTER: He K 

PROVIDER: S-EPMC10743641 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature