Combined In Silico and In Vitro Analyses to Assess the Anticancer Potential of Thiazolidinedione-Thiosemicarbazone Hybrid Molecules.

ABSTRACT: The number of people affected by cancer and antibiotic-resistant bacterial infections has increased, such that both diseases are already seen as current and future leading causes of death globally. To address this issue, based on a combined in silico and in vitro approach, we explored the anticancer potential of known antibacterials with a thiazolidinedione-thiosemicarbazone (TZD-TSC) core structure. A cytotoxicity assessment showed encouraging results for compounds 2-4, with IC₅₀ values against T98G and HepG2 cells in the low micromolar range. TZD-TSC 3 proved to be most toxic to cancer cell lines, with IC₅₀ values of 2.97 ± 0.39 µM against human hepatoma HepG2 cells and IC₅₀ values of 28.34 ± 2.21 µM against human glioblastoma T98G ce

SUBMITTER: Paneth A 

PROVIDER: S-EPMC10743653 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature