Impact of Conventional and Potential New Metal-Based Drugs on Lipid Metabolism in Osteosarcoma MG-63 Cells.

ABSTRACT: This work investigated the mechanisms of action of conventional drugs, cisplatin and oxaliplatin, and the potentially less deleterious drug Pd₂Spermine (Spm) and its Pt(II) analog, against osteosarcoma MG-63 cells, using nuclear-magnetic-resonance metabolomics of the cellular lipidome. The Pt(II) chelates induced different responses, namely regarding polyunsaturated-fatty-acids (increased upon cisplatin), suggesting that cisplatin-treated cells have higher membrane fluidity/permeability, thus facilitating cell entry and justifying higher cytotoxicity. Both conventional drugs significantly increased triglyceride levels, while Pt₂Spm maintained control levels; this may reflect enhanced apoptotic behavior for conventional drugs, but not for Pt₂Spm. Compared to

SUBMITTER: Bispo DSC 

PROVIDER: S-EPMC10743680 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature