Blood Neurofilament Levels Predict Cognitive Decline across the Alzheimer's Disease Continuum.

ABSTRACT: Neurofilament light chain (NfL) is a potential diagnostic and prognostic plasma biomarker for numerous neurological diseases including Alzheimer's disease (AD). In this study, we investigated the relationship between baseline plasma concentration of Nfl and Mild Cognitive Impairment in participants who did and did not have a clinically determined diagnosis of dementia by the end of the three-year study. Additionally, we explored the connection between baseline plasma concentration of NfL and AD dementia patients, considering their demographics, clinical features, and cognitive profiles. A total of 350 participants from the Biomarker of AmyLoid pepTide and AlZheimer's diseAse Risk (BALTAZAR) multicenter prospective study were investigated: 161 AD dementia participants and 189 MCI participan

SUBMITTER: Lehmann S 

PROVIDER: S-EPMC10743700 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature