Effect of Petiveria alliacea Extracts on Metabolism of K562 Myeloid Leukemia Cells.

ABSTRACT: Previously, studies have shown that leukemic cells exhibit elevated glycolytic metabolism and oxidative phosphorylation in comparison to hematopoietic stem cells. These metabolic processes play a crucial role in the growth and survival of leukemic cells. Due to the metabolic plasticity of tumor cells, the use of natural products has been proposed as a therapeutic alternative due to their ability to attack several targets in tumor cells, including those that could modulate metabolism. In this study, the potential of Petiveria alliacea to modulate the metabolism of K562 cell lysates was evaluated by non-targeted metabolomics. Initially, in vitro findings showed that P. alliacea reduces K562 cell proliferation; subsequently, alterations were observed in the endometabolome of cel

SUBMITTER: Rojas L 

PROVIDER: S-EPMC10743714 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature