Intestinal Microbiome Changes and Clinical Outcomes of Patients with Ulcerative Colitis after Fecal Microbiota Transplantation.

ABSTRACT:

Background and aims

Ulcerative colitis (UC) is a chronic inflammatory disease that affects many people. One of the possible ways to treat UC is fecal microbiota transplantation (FMT). In this study, changes in the intestinal microbiome and clinical outcomes of 20 patients with UC after FMT were estimated.

Methods

FMT enemas were administrated ten times, once a day, and fecal microbiota from three donors was used for each enema. The clinical outcomes were assessed after eight weeks and then via a patient survey. The 16S rRNA profiles of the gut microbiota were compared between three samplings: samples from 20 patients with UC before and after FMT and samples from 18 healthy volunteers.

Results

Clinical remission was achieved in 19 (95%) patients at week 8. Adverse even

SUBMITTER: Tikunov AY 

PROVIDER: S-EPMC10743744 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature