Synthesis of 1,3,4-Thiadiazole Derivatives and Their Anticancer Evaluation.

ABSTRACT: Thiadiazole derivatives have garnered significant attention in the field of medicinal chemistry due to their diverse pharmacological activities, including anticancer properties. This article presents the synthesis of a series of thiadiazole derivatives and investigates their chemical characterization and potential anticancer effects on various cell lines. The results of the nuclear magnetic resonance (NMR) analyses confirmed the successful formation of the target compounds. The anticancer potential was evaluated through in silico and in vitro cell-based assays using LoVo and MCF-7 cancer lines. The assays included cell viability, proliferation, apoptosis, and cell cycle analysis to assess the compounds' effects on cancer cell growth and survival. Daphnia magna was used as an inverte

SUBMITTER: Stecoza CE 

PROVIDER: S-EPMC10743895 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature