Level of Disability after Total Hip Replacement in Patients with Some COMT Gene Polymorphism.

ABSTRACT:

Background

The COMT gene encodes the enzyme catechol-O-methyltransferase, which is a key modulator of dopaminergic and adrenergic neurotransmission. Hip osteoarthritis is accompanied by reduced mobility and some level of disability. In our study, we analyzed the association between some COMT gene polymorphisms and reduced mobility in patients after total hip replacement (THR).

Methods

The operative procedures were performed on 195 patients with symptomatic and radiologically advanced hip osteoarthritis. In the postoperative follow-up, we assessed hip function with the Harris Hip Score (HHS) and the degree of disability with the Oswestry Disability Index (ODI). These procedures were repeated three times at defined intervals (one week, six weeks, and six months)

SUBMITTER: Jurewicz A 

PROVIDER: S-EPMC10743937 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature